Which topical antibiotic is a three-drug combination including Bacitracin, Polymyxin B, and Neomycin?

Which topical antibiotic is a three-drug combination including Bacitracin, Polymyxin B, and Neomycin?

• A. Neosporin
• B. Polysporin
• C. Augmentin
• D. Penicillin

Answer: (A)

The three-drug topical combination that includes Bacitracin, Polymyxin B, and Neomycin is found in Neosporin. This product blends all three antibiotics into one ointment to provide broad coverage for minor skin infections: Bacitracin disrupts bacterial cell wall synthesis, Polymyxin B targets the bacterial cell membrane (and is particularly active against gram-negative organisms), and Neomycin inhibits protein synthesis. Because Neosporin contains all three components, it matches the description of a three-drug topical combination. Polysporin, by contrast, includes only Bacitracin and Polymyxin B (two drugs), while Augmentin and Penicillin are systemic antibiotics and do not fit the topical three-drug combination described.

The three-drug topical combination that includes Bacitracin, Polymyxin B, and Neomycin is found in Neosporin. This product blends all three antibiotics into one ointment to provide broad coverage for minor skin infections: Bacitracin disrupts bacterial cell wall synthesis, Polymyxin B targets the bacterial cell membrane (and is particularly active against gram-negative organisms), and Neomycin inhibits protein synthesis. Because Neosporin contains all three components, it matches the description of a three-drug topical combination. Polysporin, by contrast, includes only Bacitracin and Polymyxin B (two drugs), while Augmentin and Penicillin are systemic antibiotics and do not fit the topical three-drug combination described.