Which of the following is NOT an example of a Sulfonylurea?

Which of the following is NOT an example of a Sulfonylurea?

• A. Glipizide
• B. Pioglitazone
• C. Glyburide
• D. Chlorpropamide

Answer: (B)

Sulfonylureas work by stimulating the pancreas to secrete more insulin. They do this by closing KATP channels on beta cells, which triggers insulin release. Drugs that belong to this class include glipizide, glyburide, and chlorpropamide. Pioglitazone, on the other hand, is a thiazolidinedione. TZDs don’t stimulate insulin secretion; they activate PPAR-gamma receptors to improve the body's sensitivity to insulin in muscle and adipose tissue. Because its mechanism and drug class are different, pioglitazone is not a sulfonylurea.

Sulfonylureas work by stimulating the pancreas to secrete more insulin. They do this by closing KATP channels on beta cells, which triggers insulin release. Drugs that belong to this class include glipizide, glyburide, and chlorpropamide.

Pioglitazone, on the other hand, is a thiazolidinedione. TZDs don’t stimulate insulin secretion; they activate PPAR-gamma receptors to improve the body's sensitivity to insulin in muscle and adipose tissue. Because its mechanism and drug class are different, pioglitazone is not a sulfonylurea.