Which of the following is NOT considered an NSAID?

Which of the following is NOT considered an NSAID?

• A. Aspirin
• B. Fluticasone
• C. Indomethacin
• D. Celecoxib

Answer: (B)

Nonsteroidal anti-inflammatory drugs lower inflammation mainly by blocking cyclooxygenase enzymes (COX-1 and COX-2), which reduces prostaglandin production involved in pain, inflammation, and fever. This mechanism is typical of aspirin, indomethacin, and celecoxib. Fluticasone is a corticosteroid; it doesn’t inhibit COX enzymes. Instead, it activates glucocorticoid receptors to suppress inflammatory gene expression and mediator production, giving anti-inflammatory effects through a different pathway. Because of this, fluticasone is not an NSAID.

Nonsteroidal anti-inflammatory drugs lower inflammation mainly by blocking cyclooxygenase enzymes (COX-1 and COX-2), which reduces prostaglandin production involved in pain, inflammation, and fever. This mechanism is typical of aspirin, indomethacin, and celecoxib. Fluticasone is a corticosteroid; it doesn’t inhibit COX enzymes. Instead, it activates glucocorticoid receptors to suppress inflammatory gene expression and mediator production, giving anti-inflammatory effects through a different pathway. Because of this, fluticasone is not an NSAID.