Which medication is NOT commonly associated with Steven Johnson Syndrome?

Which medication is NOT commonly associated with Steven Johnson Syndrome?

• A. Erythromycin
• B. Sulfonamides
• C. Bactrim
• D. Amoxicillin

Answer: (A)

Steven-Johnson syndrome is a severe hypersensitivity reaction that shows up more often with certain drugs than others. Among antibiotics, sulfonamides (like sulfamethoxazole-trimethoprim, Bactrim) have a well-established association with SJS, making them classic culprits. Amoxicillin can rarely be linked to SJS, but such cases are uncommon. Erythromycin, a macrolide, has very few, if any, strong associations with SJS, so it is not considered a common cause. Therefore, erythromycin is the choice not typically linked to Stevens-Johnson syndrome.

Steven-Johnson syndrome is a severe hypersensitivity reaction that shows up more often with certain drugs than others. Among antibiotics, sulfonamides (like sulfamethoxazole-trimethoprim, Bactrim) have a well-established association with SJS, making them classic culprits. Amoxicillin can rarely be linked to SJS, but such cases are uncommon. Erythromycin, a macrolide, has very few, if any, strong associations with SJS, so it is not considered a common cause. Therefore, erythromycin is the choice not typically linked to Stevens-Johnson syndrome.