Which GI medication is a Proton Pump Inhibitor?

Which GI medication is a Proton Pump Inhibitor?

• A. Cimetidine
• B. Omeprazole
• C. Sucralfate
• D. Famotidine

Answer: (B)

Proton Pump Inhibitors block the final step of acid production in the stomach by inhibiting the H+/K+ ATPase enzyme on gastric parietal cells, leading to strong and longer-lasting reductions in gastric acidity. Omeprazole is a classic PPI and works by being activated in the acidic environment of the parietal cell canaliculi and then irreversibly inhibiting the proton pump, which substantially lowers acid secretion for a day or two after starting therapy. The other options work differently: some are H2 receptor blockers that reduce acid by blocking histamine stimulation on parietal cells and are typically less potent; one is a mucosal protectant that doesn’t lower acid at all but helps shield the mucosa. So omeprazole fits the Proton Pump Inhibitor class.

Proton Pump Inhibitors block the final step of acid production in the stomach by inhibiting the H+/K+ ATPase enzyme on gastric parietal cells, leading to strong and longer-lasting reductions in gastric acidity. Omeprazole is a classic PPI and works by being activated in the acidic environment of the parietal cell canaliculi and then irreversibly inhibiting the proton pump, which substantially lowers acid secretion for a day or two after starting therapy. The other options work differently: some are H2 receptor blockers that reduce acid by blocking histamine stimulation on parietal cells and are typically less potent; one is a mucosal protectant that doesn’t lower acid at all but helps shield the mucosa. So omeprazole fits the Proton Pump Inhibitor class.