Spironolactone and Triamterene spare which main ion?

Spironolactone and Triamterene spare which main ion?

• A. Sodium (Na+)
• B. Potassium (K+)
• C. Calcium (Ca2+)
• D. Magnesium (Mg2+)

Answer: (B)

These drugs are potassium-sparing diuretics, so they spare potassium. Spironolactone blocks aldosterone receptors in the collecting ducts, which reduces sodium reabsorption and potassium secretion, producing diuresis with preserved potassium. Triamterene directly inhibits epithelial sodium channels in the late distal tubule and collecting duct, lowering sodium reabsorption and the electrochemical gradient that drives potassium loss, also conserving potassium. Sodium continues to be excreted as part of the diuretic effect, but potassium is the ion spared. Calcium and magnesium aren’t the primary ions affected in this mechanism. Clinically, monitor for potential hyperkalemia, especially with other renin–angiotensin system inhibitors or kidney impairment.

These drugs are potassium-sparing diuretics, so they spare potassium. Spironolactone blocks aldosterone receptors in the collecting ducts, which reduces sodium reabsorption and potassium secretion, producing diuresis with preserved potassium. Triamterene directly inhibits epithelial sodium channels in the late distal tubule and collecting duct, lowering sodium reabsorption and the electrochemical gradient that drives potassium loss, also conserving potassium. Sodium continues to be excreted as part of the diuretic effect, but potassium is the ion spared. Calcium and magnesium aren’t the primary ions affected in this mechanism. Clinically, monitor for potential hyperkalemia, especially with other renin–angiotensin system inhibitors or kidney impairment.