______ is a CNS AcHE inhibitor that is used to treat Alzheimer's disease by being an indirect cholinergic agonist.

______ is a CNS AcHE inhibitor that is used to treat Alzheimer's disease by being an indirect cholinergic agonist.

• A. Donepezil
• B. Rivastigmine
• C. Galantamine
• D. Memantine

Answer: (A)

Acetylcholinesterase inhibitors work by blocking the breakdown of acetylcholine in the brain, boosting cholinergic transmission to help cognitive symptoms in Alzheimer’s disease. The best example here is donepezil, a CNS-penetrant, reversible acetylcholinesterase inhibitor that increases synaptic acetylcholine and has shown meaningful cognitive benefits in mild to severe Alzheimer’s disease. Memantine is not an acetylcholinesterase inhibitor; it acts as an NMDA receptor antagonist, so it doesn’t fit the mechanism described. Rivastigmine and galantamine are also acetylcholinesterase inhibitors, with rivastigmine also targeting butyrylcholinesterase and galantamine providing some nicotinic receptor modulation, but donepezil is the most classic and widely used CNS AChE inhibitor for this purpose.

Acetylcholinesterase inhibitors work by blocking the breakdown of acetylcholine in the brain, boosting cholinergic transmission to help cognitive symptoms in Alzheimer’s disease. The best example here is donepezil, a CNS-penetrant, reversible acetylcholinesterase inhibitor that increases synaptic acetylcholine and has shown meaningful cognitive benefits in mild to severe Alzheimer’s disease. Memantine is not an acetylcholinesterase inhibitor; it acts as an NMDA receptor antagonist, so it doesn’t fit the mechanism described. Rivastigmine and galantamine are also acetylcholinesterase inhibitors, with rivastigmine also targeting butyrylcholinesterase and galantamine providing some nicotinic receptor modulation, but donepezil is the most classic and widely used CNS AChE inhibitor for this purpose.